Rescale a Pixel Mask?

Hello:                                                                                                             Level: Newbie    OS: Win7 64bit    Ps:Cs6

I am working on a tut and it calls for the use of a Pixel Mask.

However, once I get through it I plan to use the resulting image at various sizes.

I am creating the image w/a canvas size of 425px by 200px and the object itself is roughly 155px by 45px (give or take a pixel or so).

I then plan to scale it down to various sizes and so my question is will the Pixel Mask cause a problem with artifacts and interpolated bluriness?

ie, will saving for the web at smaller sizes cause a problem with the clarity?

Thank you in advance for your time